[Genetic control of production of a lymphokine inhibiting macrophage migration in mice]

Genetic control of the production of the macrophage migration inhibitory factor (MIF) by lymphocytes in mice is studied. Dynamics of the MIF production by perinoteal lymphocytes, lymphocytes of the lymphatic nodes and spleen to specific antigen is investigated. Interstrain differences in the dynamics of MIF production were found: mice of H-2b and H-2d haplotype were highly reactive to tuberculin, mice with H-2k haplotype were low responding. The hybridological analysis has revealed that the character of the MIF production is inherited by dominant type and is controlled by several genes. One genes, responsible for MIF production to tuberculin, are linked with H-2 complex of the major hystocompatibility system, other are not linked.