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Decrease in cholera toxin-binding T cells in aged mice and human volunteers

S Tsuru, Y Zinnaka, K Nomoto

    International Archives of Allergy and Applied Immunology
    |January 1, 1981
    PubMed
    Summary
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    The immune system ages, with fewer T cells binding cholera toxin in older mice and humans. This toxin-binding capacity could indicate immune system aging.

    Area of Science:

    • Immunology
    • Aging Research
    • Cell Biology

    Background:

    • The immune system undergoes changes with age, impacting its function.
    • Cholera toxin is a well-characterized bacterial toxin that interacts with specific cell surface receptors.

    Purpose of the Study:

    • To investigate the effect of aging on the T cell capacity to bind cholera toxin.
    • To determine if cholera toxin binding can serve as a biomarker for immune system aging.

    Main Methods:

    • Utilized fluorescence-activated cell sorting (FACS) to analyze T cell populations.
    • Quantified the binding of cholera toxin to T cells from young and aged mice and human volunteers.

    Main Results:

    • A reduced number of T cells capable of binding high concentrations of cholera toxin was observed in aged mice compared to young mice.

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  • Similarly, aged human volunteers exhibited a lower number of T cells with high cholera toxin binding capacity than younger individuals.

    • Conclusions:

    • The capacity of T cells to bind cholera toxin decreases with age in both mice and humans.
    • Cholera toxin binding may represent a potential indicator for assessing immune system aging.