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Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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Escherichia coli K-12 clones that overproduce dam methylase are hypermutable

G E Herman, P Modrich

    Journal of Bacteriology
    |January 1, 1981
    PubMed

    Abstract:

    A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.

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