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Related Experiment Videos

Local immune system in the developing fetal larynx

T Nakashima, K Makishima, S Komiyama

    The Laryngoscope
    |March 1, 1981
    PubMed
    Summary

    The fetal larynx develops a glandular system by the fifth month of gestation. Secretory component (SC) synthesis begins early, suggesting the local immune system is present in the developing human larynx.

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    Area of Science:

    • Anatomy
    • Immunology
    • Developmental Biology

    Background:

    • The larynx's glandular system and immune development are crucial for respiratory health.
    • Understanding fetal laryngeal development provides insights into congenital conditions.

    Purpose of the Study:

    • To investigate the developmental timeline of the human fetal larynx's glandular system.
    • To examine the presence and synthesis of immune components within the fetal larynx.

    Main Methods:

    • Histopathological examination of 12 human fetal larynges.
    • Immunofluorescent techniques to detect immunoglobulins and secretory component (SC).

    Main Results:

    • Glandular buds observed from the fourth month; glandular distribution evident by the fifth month.
    • Presence of IgG detected, with minimal IgA, IgM, and IgE.
    • Secretory component (SC) synthesis initiated by the fourth month in serous glands.

    Conclusions:

    • The human fetal larynx possesses an inherently acquired local immune system via SC synthesis.
    • SC in the fetal larynx is capable of binding IgA to form SIgA, indicating early mucosal immune readiness.

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