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Related Experiment Videos

Clocked cell cycle clocks

L N Edmunds, K J Adams

    Science (New York, N.Y.)
    |March 6, 1981
    PubMed
    Summary

    The cell division cycle acts as a biological clock, measuring time and influenced by environmental conditions. Programmable clocks can regulate this cycle, potentially generating circadian rhythms and explaining cell generation time variability.

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    Area of Science:

    • Cell Biology
    • Chronobiology
    • Biophysics

    Background:

    • The cell division cycle in mammalian cells and microorganisms exhibits both deterministic and probabilistic characteristics.
    • This cycle functions as a biological clock, measuring time based on a sequence of events under specific environmental conditions.

    Purpose of the Study:

    • To explore the regulatory mechanisms of the cell division cycle.
    • To investigate the role of programmable clocks in generating circadian periodicities.
    • To understand how cellular generation time variability arises.

    Main Methods:

    • Analysis of cell division cycle dynamics.
    • Modeling of clock-regulated cellular processes.
    • Investigating interactions between cell cycle and circadian pacemakers.

    Main Results:

    • The cell division cycle inherently measures time, influenced by environmental factors.
    • Programmable clocks can interact with circadian pacemakers to induce circadian rhythms.
    • Time-inserting mechanisms within these clocks account for variations in cellular generation times.

    Conclusions:

    • The cell division cycle serves as a fundamental timekeeping process in cells.
    • Circadian clocks can modulate the cell division cycle, leading to rhythmic behaviors.
    • Understanding these clock mechanisms is crucial for explaining cellular generation time variability.

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