[Stability of insulin-bearing liposomes (author's transl)]

Stability and integrity of 125I-insulin loaded liposomes are temperature dependent. Only storage close to the phase transition temperature ensures their chromatographic integrity even after nine days. The pH of the buffer also affects the stability of the insulinliposomes. pH changes to 6.0 or 8.5 alter the elution pattern of the liposomes. The sensitivity of insulinliposomes to temperature and pH is of importance with regard to their in vivo application.