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Carcinogenicity of dichlorvos

M D Reuber

    Clinical Toxicology
    |January 1, 1981
    PubMed
    Summary

    Dichlorvos, an organophosphate insecticide, is widely used but its carcinogenicity in animals requires thorough review. This analysis examines multiple animal studies to assess potential cancer risks associated with dichlorvos exposure.

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    Area of Science:

    • Toxicology
    • Environmental Health
    • Pesticide Science

    Background:

    • Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is a widely used organophosphate insecticide.
    • It is applied in agriculture, industry, and domestic settings for pest control.
    • Exposure occurs via inhalation, dermal contact, or ingestion of residues.

    Purpose of the Study:

    • To review all available animal studies on the carcinogenicity of dichlorvos.
    • To consolidate findings from various laboratory studies to assess cancer risk.

    Main Methods:

    • Compilation and review of six key animal studies: NCI Rat and Mouse Studies, Tunstall Rat Study, Kettering Rat and Dog Studies, and Shell Swine Study.
    • Histological examination and diagnosis of tissue samples from NCI studies.
    • Statistical analysis using Fisher's exact test and trend tests.

    Main Results:

    • The review encompasses multiple animal models including rats, mice, dogs, and swine.
    • Specific studies focused on different exposure routes and durations.
    • Statistical significance was determined using established methods.

    Conclusions:

    • This review aims to provide a comprehensive overview of dichlorvos carcinogenicity data.
    • The findings are based on rigorous examination of histological evidence and statistical analysis.
    • Further conclusions regarding carcinogenicity await detailed synthesis of all reviewed studies.

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