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A uremic peptide containing polyamine: formation and possible role in uremic hypertriglyceridemia
Physiological Chemistry and Physics
|January 1, 1980
Summary
Increased peptidic compounds in uremic blood plasma were identified. A novel spermidinepeptide from intestinal bacteria may contribute to uremia complications like altered insulin action and atherosclerosis.
Area of Science:
- Biochemistry
- Nephrology
- Microbiology
Background:
- Uremic patients exhibit elevated levels of peptidic compounds in blood plasma.
- Intestinal bacteria are implicated in the production of potentially toxic peptides.
Purpose of the Study:
- To investigate the origin and characteristics of increased peptides in uremic patients.
- To explore the role of a specific peptide in the pathophysiology of chronic uremia.
Main Methods:
- Isolation and characterization of a novel peptide from peritoneal dialysate and blood plasma.
- Analysis of the peptide's molecular structure, including the absence of glutamic acid.
- Investigation of the peptide's interaction with insulin and its effect on adipose cell metabolism.
Main Results:
- A strongly basic peptide containing covalently bound spermidine was isolated from uremic patients' peritoneal dialysate and blood plasma.
- The peptide's molecular structure lacks glutamic acid, suggesting a non-mammalian enzyme synthesis pathway.
- The spermidinepeptide forms a stable complex with insulin, altering its metabolic effects on adipose cells.
Conclusions:
- Intestinal bacteria likely contribute to the synthesis of a novel spermidinepeptide found in uremic patients.
- This spermidinepeptide may play a role in altered insulin action, hypertriglyceridemia, and accelerated atherosclerosis in chronic uremia.