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The retinol-binding protein

L Rask, H Anundi, J Böhme

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1980
    PubMed
    Summary
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    Retinol-binding protein (RBP) transports vitamin A from the liver to tissues. This review details RBP

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Physiology

    Background:

    • Vitamin A is essential for numerous physiological processes.
    • Vitamin A is stored in the liver and transported via Retinol-binding protein (RBP).
    • RBP forms a complex with thyroxine-binding prealbumin in plasma.

    Purpose of the Study:

    • To review available data on the Retinol-binding protein (RBP) system.
    • To elucidate the structure, function, and regulation of RBP.
    • To describe the mechanism of vitamin A delivery to epithelial tissues.

    Main Methods:

    • Review of existing literature on RBP.
    • Analysis of the primary structure of RBP.
    • Examination of RBP's interaction with vitamin A, prealbumin, and cell receptors.

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    Main Results:

    • The complete primary structure of RBP has been determined.
    • Plasma RBP concentration is regulated by vitamin A status, with reduced secretion in deficiency.
    • RBP delivers vitamin A to epithelial cells via cell membrane receptors.

    Conclusions:

    • RBP plays a crucial role in vitamin A transport and delivery.
    • Cellular uptake of vitamin A alters RBP's affinity for prealbumin.
    • RBP-prealbumin complexes are eventually degraded after vitamin A delivery.