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Lysosomal enzyme in endotoxin shock

K Mori, K Takagi, M Maeno

    Surgery, Gynecology & Obstetrics
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Lysosomal enzymes released during endotoxin shock do not appear to cause irreversible harm. Studies in rats show these enzymes do not affect survival rates or blood pressure, suggesting a minimal role in shock progression.

    Area of Science:

    • Biochemistry
    • Pathophysiology
    • Toxicology

    Background:

    • Lysosomal enzymes are released into circulation during various shock conditions.
    • Their specific contribution to the development of irreversible shock remains debated.

    Purpose of the Study:

    • To investigate the impact of administering lysosomal enzymes on normal rats and rats subjected to endotoxin-induced shock.
    • To determine if these enzymes play a significant role in the progression and mortality associated with endotoxin shock.

    Main Methods:

    • Lysosomal enzymes were isolated from isologous rat liver.
    • Enzymes were administered intravenously or intraperitoneally to normal rats and rats receiving lethal or sub-lethal doses of endotoxin.
    • Hemodynamic parameters, survival time, and mortality rates were monitored.

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    Main Results:

    • Administration of lysosomal enzymes to normal rats produced no observable hemodynamic effects.
    • In rats with lethal endotoxin shock, lysosomal enzyme administration did not alter survival time or blood pressure dynamics.
    • Sub-lethal doses of endotoxin combined with lysosomal enzymes did not change the overall mortality rate.

    Conclusions:

    • The findings suggest that lysosomal enzymes circulating during endotoxin shock may not be a major factor in the irreversibility of the shock state.
    • Further research may be needed to fully elucidate the complex mechanisms of shock progression.