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Related Experiment Videos

Evaluation of cefaclor

J E Derry

    American Journal of Hospital Pharmacy
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Cefaclor is a new oral cephalosporin antibiotic with a broad spectrum of activity, effective against various infections. While generally safe with mild side effects, its clinical superiority over other antibiotics requires further study.

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    Area of Science:

    • Pharmacology
    • Microbiology
    • Clinical Medicine

    Background:

    • Cefaclor is a novel semisynthetic cephalosporin antibiotic, closely related to cephalexin.
    • It exhibits favorable oral absorption when taken on an empty stomach, with renal excretion being the primary elimination route.

    Purpose of the Study:

    • To review the chemistry, pharmacology, pharmacokinetics, antibacterial spectrum, clinical applications, dosage, adverse effects, and cost of cefaclor.
    • To assess the efficacy and safety profile of cefaclor in treating various bacterial infections.

    Main Methods:

    • Review of existing literature on cefaclor.
    • Analysis of its pharmacokinetic properties, including absorption and elimination.
    • Evaluation of its in vitro and in vivo antibacterial spectrum.

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  • Assessment of clinical trial data for efficacy and adverse reactions.

    • Main Results:

    • Cefaclor demonstrates a broad spectrum of activity against gram-negative and gram-positive bacteria, with enhanced susceptibility of key pathogens like E. coli and H. influenzae compared to cephalexin.
    • Effective in treating urinary tract, respiratory, skin, and soft tissue infections, as well as pediatric otitis media.
    • Adverse reactions are predominantly mild gastrointestinal disturbances, affecting a small patient subset.

    Conclusions:

    • Cefaclor is an effective antibiotic for a range of common infections.
    • Its efficacy against beta-lactamase-producing H. influenzae warrants further investigation.
    • Clinical superiority over less expensive antibiotics has not been established, suggesting a need for comparative studies.