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Related Experiment Videos

Quantification of hyperbaric oxygen-induced toxicity utilizing a malarial system

N J Rencricca, R M Coleman, M D Altschule

    Aviation, Space, and Environmental Medicine
    |February 1, 1981
    PubMed
    Summary
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    Hyperbaric oxygen (HBO) exposure reduced malaria parasite levels in mice by promoting the destruction of infected red blood cells. This quantitative system offers a sensitive method for studying HBO toxicity.

    Area of Science:

    • Biomedical Science
    • Toxicology
    • Parasitology

    Background:

    • Developing quantitative methods to assess hyperbaric oxygen (HBO) toxicity is crucial.
    • Malaria infection impacts red blood cells, making it a relevant model for studying blood-related toxicities.

    Purpose of the Study:

    • To establish a quantitative system for evaluating hyperbaric oxygen (HBO) toxicity.
    • To investigate the effect of HBO exposure on malaria-infected mice.

    Main Methods:

    • Mice infected with Plasmodium berghei berghei were exposed to 100% oxygen at 3 ATA.
    • Erythrocyte counts and percentage of parasitized red blood cells were monitored at 25, 48, and 72 hours post-exposure.
    • Data were compared between HBO-exposed and non-exposed infected control groups.

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    Main Results:

    • No significant difference in total erythrocyte counts between HBO-exposed and control groups.
    • Percent parasitized red blood cells were significantly reduced (55-60% of control values) in HBO-exposed mice at 24, 48, and 72 hours.
    • Suggests preferential hemolysis of P. berghei-infected erythrocytes due to HBO exposure.

    Conclusions:

    • HBO exposure can selectively reduce parasitemia in malaria-infected mice.
    • The proposed system demonstrates high selectivity and sensitivity for quantifying HBO-induced toxicity.
    • This model is valuable for studying HBO toxicity over several days.