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Related Experiment Videos

Pituitary surgery for endocrine disorders

J D Nabarro

    Clinical Endocrinology
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Pituitary surgery is reviewed for growth hormone, corticotrophin, and prolactin over-production. Trans-sphenoidal surgery is emphasized for acromegaly, while bromocriptine may be preferred for small prolactinomas.

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    Area of Science:

    • Neurosurgery
    • Endocrinology
    • Oncology

    Background:

    • Pituitary surgery is a key treatment for hormonal over-production.
    • Neuroradiological techniques aid in diagnosis and surgical planning.

    Purpose of the Study:

    • To review pituitary surgery for growth hormone, corticotrophin, and prolactin over-production.
    • To discuss surgical indications, techniques, and outcomes.

    Main Methods:

    • Review of neuroradiological techniques (CT, air-encephalography, cavernous sinus venography).
    • Consideration of transcranial versus trans-sphenoidal surgical approaches.
    • Analysis of treatment outcomes for acromegaly, Cushing's disease, Nelson's syndrome, and prolactinomas.

    Main Results:

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    • Trans-sphenoidal surgery is highlighted for acromegaly.
    • Bromocriptine is often preferred over surgery for small prolactinomas.
    • Complications from trans-sphenoidal surgery are generally low, with 14% experiencing panhypopituitarism.

    Conclusions:

    • Pituitary surgery is effective for specific hormonal disorders.
    • Treatment choice depends on tumor type, size, and hormone produced.
    • Careful patient selection and post-operative management are crucial.