Jove
Visualize
Contact Us

Related Experiment Videos

Age, estrogen, and the endometrium

J Aiman

    Clinical Obstetrics and Gynecology
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Postmenopausal women produce biologically active estrogen extraglandularly, which may contribute to uterine bleeding and endometrial cancer. Progesterone can counteract some estrogen effects, but evidence suggests estrogen plays a role in endometrial cancer development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Elevated follicular fluid angiotensin II and pregnancy outcome.

    Fertility and sterility·1995
    Same author

    Virilizing ovarian tumors.

    Clinical obstetrics and gynecology·1991
    Same author

    Pituitary sarcoidosis causing secondary amenorrhea. A case report.

    The Journal of reproductive medicine·1990
    Same author

    Level of reading difficulty in the American College of Obstetricians and Gynecologists patient education pamphlets.

    Obstetrics and gynecology·1989
    Same author

    Inability of sonography to detect imminent ovulation.

    AJR. American journal of roentgenology·1989
    Same author

    A semiquantitative human chorionic gonadotropin assay for the detection of ectopic pregnancy.

    Obstetrics and gynecology·1988
    Same journal

    Obstetric Care for Patients With Cognitive Disabilities.

    Clinical obstetrics and gynecology·2026
    Same journal

    Dissecting the Americans With Disabilities Act (ADA) Requirements when Approaching Obstetric Patients With Disabilities: How to Ensure Your Spaces are Accessible for All.

    Clinical obstetrics and gynecology·2026
    Same journal

    Clinician Comfort and Barriers to the Obstetric and Gynecologic Care of Patients With Disabilities.

    Clinical obstetrics and gynecology·2026
    Same journal

    Obstetric Care for Patients With Visual Impairments: Preconception Counseling Through Postpartum Care.

    Clinical obstetrics and gynecology·2026
    Same journal

    Menstrual Management and Contraception for Patients With Disabilities.

    Clinical obstetrics and gynecology·2026
    Same journal

    Favoring Elective Hospitalization in Pregnancies With Vasa Previa.

    Clinical obstetrics and gynecology·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Endocrinology
    • Gynecologic Oncology
    • Reproductive Medicine

    Background:

    • Postmenopausal women can produce estrogen extraglandularly, not from the ovaries.
    • This extraglandular estrogen production can be substantial, sometimes leading to uterine bleeding and adenocarcinoma.
    • The biological activity of this postmenopausal estrogen is confirmed.

    Purpose of the Study:

    • To review the evidence supporting the production and activity of extraglandular estrogen in postmenopausal women.
    • To discuss the antagonistic role of progesterone on estrogen's biological effects.
    • To evaluate the cumulative evidence suggesting a causal link between estrogen and endometrial cancer.

    Main Methods:

    • Review of clinical and experimental evidence.

    Related Experiment Videos

  • Analysis of hormonal production in postmenopausal women.
  • Assessment of estrogen's biological activity and progesterone's antagonism.

    • Main Results:

    • Postmenopausal women produce biologically active estrogen from extraglandular sources.
    • This estrogen can be linked to uterine bleeding and adenocarcinoma.
    • Progesterone demonstrates antagonistic effects on many estrogen-mediated biological actions.

    Conclusions:

    • While not definitive proof, the evidence strongly suggests a causal role for estrogen in endometrial cancer.
    • Extraglandular estrogen production and its biological activity are key factors in postmenopausal gynecologic health.
    • Further research into the estrogen-progesterone balance is warranted for understanding and preventing endometrial cancer.