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Gastric Emptying

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Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...

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Related Experiment Video

Updated: Jun 1, 2026

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [¹³C]-octanoic Acid Breath Test

Published on: March 23, 2013

Measuring gastric volume by dye dilution

|February 1, 1981

Summary

This study mathematically analyzes the double sampling method for gastric volume measurement, revealing it magnifies analytical errors. Modifications, like using dye-free water and doubling dye concentration, significantly reduce these errors in gastric volume calculations.

Area of Science:

Gastroenterology
Analytical Chemistry
Mathematical Modeling

Background:

The double sampling method is used for measuring gastric volumes.
This method is susceptible to analytical errors in dye concentration.
These errors can impact the accuracy of calculated gastric volumes.

Purpose of the Study:

To mathematically analyze the double sampling method for gastric volume measurement.
To identify sources of error in the method.
To propose modifications to reduce these errors.

Main Methods:

Mathematical analysis of the double sampling method.
Investigating the impact of analytical error, initial dye concentration, analysis cycles, and dye-to-volume ratio.
Implementing modifications including starting with dye-free water and doubling dye concentration in serial measurements.

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Main Results:

The double sampling method magnifies random analytical errors in dye concentration.
Errors in calculated gastric volume are dependent on analytical error extent, initial dye concentration, repetition, and dye-to-volume ratio.
Modifications significantly reduced calculated volume errors, preventing their increase with successive measurements.

Conclusions:

The original double sampling method inherently magnifies analytical errors.
Modified procedures, specifically using dye-free water and adjusted dye concentrations, substantially improve accuracy.
These modifications mitigate the limitations of the original double sampling method for gastric volume determination.