Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria

C Adam, M Géniteau, M Gougerot-Pocidalo

    Infection and Immunity
    |February 1, 1981
    PubMed
    Summary

    Cerebral malaria is linked to a strong immune response and complement activation, indicated by cryoglobulins and immune complexes. Benign malaria shows significantly lower levels of these markers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The AI Innerve Algorithm: Automatic Reproducible Reading for Intraepidermal Nerve Fiber Density Analysis, a New Tool for Small-Fiber Neuropathy Diagnosis.

    European journal of neurology·2026
    Same author

    Entropy Spectroscopy of a Bilayer Graphene Quantum Dot.

    Physical review letters·2025
    Same author

    Homozygous DNAJB4 deletion revealing myopathy with acute respiratory failure.

    Revue neurologique·2025
    Same author

    Relativistic moduli space and critical velocity in kink collisions.

    Physical review. E·2023
    Same author

    [Peripheral neuropathies during systemic diseases: Part II (vasculitis)].

    La Revue de medecine interne·2023
    Same author

    [Peripheral neuropathies during systemic diseases: Part I (connective tissue diseases and granulomatosis)].

    La Revue de medecine interne·2023

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Pathogenesis of Malaria

    Background:

    • Plasmodium falciparum malaria can manifest as benign or severe cerebral malaria.
    • The role of immune complexes and complement activation in cerebral malaria pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the presence and significance of cryoglobulins, circulating immune complexes, and hypocomplementemia in patients with cerebral malaria compared to benign malaria.
    • To explore the association between immune markers, complement activation, and clinical outcomes like thrombocytopenia.

    Main Methods:

    • Studied 32 patients with Plasmodium falciparum malaria (9 cerebral, 23 benign).
    • Assessed for cryoglobulins and circulating immune complexes using a C1q-binding assay.
    • Measured serum complement component 3 breakdown products (C3d) and assessed hypocomplementemia.

    Related Experiment Videos

  • Correlated immune marker levels with clinical findings, including thrombocytopenia.

    • Main Results:

    • Eight of nine cerebral malaria patients had cryoglobulins, immune complexes, and hypocomplementemia.
    • Raised C3d levels were observed in seven tested cerebral malaria patients.
    • Peak immune complex and C3d levels correlated with thrombocytopenia in cerebral malaria.
    • Only 3 of 23 benign malaria patients showed cryoglobulins/immune complexes; 5 had hypocomplementemia.

    Conclusions:

    • The intensity of the immune response and complement activation are likely crucial in cerebral malaria development.
    • Immune complexes and complement activation are significantly more pronounced in cerebral malaria than in benign infections.
    • These findings highlight potential targets for understanding and managing severe malaria.