Herpes gestationis. A possible association with autoimmune thyrotoxicosis (Graves' disease)

Herpes gestationis (HG) is almost identical to bullous pemphigoid (BP) in its immunopathology. Although BP has been reported in association with autoimmune diseases, no such association has previously been noted with HG. We describe three patients with HG who also had Graves' disease, and, in addition, one of these patients had alopecia totalis and ulcerative colitis. All three patients possessed the human lymphocyte antigen HLA-B8.