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Pathologic changes in striated muscles in leprosy

S Kaur, A K Malik, B Kumar

    Leprosy in India
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Leprosy patients showed no significant muscle damage in biopsies, despite the presence of Mycobacterium leprae bacilli. Muscle striations, fibrosis, and necrosis were absent, indicating preserved muscle integrity.

    Area of Science:

    • Medical Microbiology
    • Neuropathology
    • Muscle Histopathology

    Background:

    • Leprosy, a chronic infectious disease, primarily affects the skin, peripheral nerves, and macrophages.
    • Muscle involvement in leprosy, particularly lepromatous forms, requires detailed histopathological examination.

    Purpose of the Study:

    • To investigate the histopathological changes in muscle biopsies from adult male leprosy patients.
    • To correlate the bacterial index (BI) with observed muscle tissue alterations.

    Main Methods:

    • Analysis of 18 muscle biopsies from adult male patients with lepromatous and borderline lepromatous leprosy.
    • Histopathological examination focusing on muscle striations, fibrosis, necrosis, and cellular infiltration.
    • Assessment of Mycobacterium leprae (bacilli) presence and distribution.

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    Main Results:

    • Absence of granuloma in most biopsies, with foamy histiocytes observed in the intermysial region.
    • Solid staining bacilli detected in otherwise normal-appearing muscle tissue.
    • No significant muscle damage observed, including loss of striations, fatty changes, sarcolemmal alterations, fibrosis, or necrosis.

    Conclusions:

    • Muscle tissue in lepromatous leprosy patients may harbor Mycobacterium leprae without exhibiting overt histopathological damage.
    • The absence of significant muscle degeneration suggests potential resilience or early-stage involvement in these patients.