Cytologic evidence for disseminated immunoblastic lymphoma

Area of Science:

• Oncology
• Hematology
• Pathology

Background:

• Immunoblastic lymphoma is a rare, aggressive non-Hodgkin lymphoma.
• Pregnancy can influence the presentation and management of hematologic malignancies.

Observation:

• An 18-year-old woman presented with disseminated immunoblastic lymphoma during her first pregnancy.
• The lymphoma was detected in sputum, pleural fluid, cerebrospinal fluid, urine, lymph nodes, bone marrow, and peripheral blood.

Findings:

• Cytologic examination of various body fluids confirmed widespread disease.
• Combined therapy, including termination of pregnancy and chemotherapy, achieved complete clinical and cytologic remission.

Implications:

• Cytologic analysis of body fluids serves as a valuable, noninvasive tool for staging and monitoring lymphoma.
• This case underscores the importance of multidisciplinary management for pregnant patients with aggressive cancers.