Related Experiment Video

Updated: Aug 4, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

Removal and excretion of immunoreactive rat growth hormone by the isolated kidney

R Rabkin, T I Gottheiner, V S Fang

    The American Journal of Physiology
    |April 1, 1981
    PubMed

    More Related Videos

    An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney10:14

    An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

    Published on: November 1, 2018

    A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection06:59

    A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

    Published on: February 2, 2022

    Related Concept Videos

    Drug Elimination by Renal Route: Glomerular Filtration01:17

    Drug Elimination by Renal Route: Glomerular Filtration

    The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...
    Drug Elimination by Renal Route: Tubular Secretion01:15

    Drug Elimination by Renal Route: Tubular Secretion

    Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
    Renal Drug Excretion: Overview01:15

    Renal Drug Excretion: Overview

    As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
    A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules out...
    Renal Drug Excretion: Glomerular Filtration01:02

    Renal Drug Excretion: Glomerular Filtration

    The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
    Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
    Renal Drug Excretion: Tubular Reabsorption01:25

    Renal Drug Excretion: Tubular Reabsorption

    Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
    Renal Drug Excretion: Tubular Secretion01:28

    Renal Drug Excretion: Tubular Secretion

    Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...