Potency test of inactivated polio vaccines in guinea pigs

A trial with five different inactivated polio vaccines offered an opportunity to compare children's antibody titres with the antibody responses in guinea-pigs elicited by the same batches of vaccines. The potency test in guinea-pigs was carried out according to the European Pharmacopoeia. Polio antibodies were determined by the neutralization test in Vero cell tubes. In our experience the potency test according to the European Pharmacopoeia is suitable for comparing different batches of vaccines manufactured in the same laboratory, but not for comparing vaccines prepared by different manufacturers.