[Menstrual cycle changes during consecutive artificial insemination therapy and their treatment]

Area of Science:

• Reproductive endocrinology
• Human reproduction
• Infertility treatments

Context:

• Artificial insemination therapy by donor (AID) is associated with significant emotional stress.
• Prolonged insemination treatment can lead to irregular or anovulatory cycles, impacting conception.
• Persistent late ovulation is a common cause of conception failure in AID treatments.

Purpose:

• To investigate the efficacy of early ovulation timing using luteinizing hormone-releasing hormone (LH-RH) analogues in women undergoing AID.
• To determine if interventions can mitigate stress-induced failures in artificial insemination therapy.
• To improve pregnancy rates in patients undergoing donor insemination.

Summary:

• High dosages of synthetic LH-releasing hormone (LH-RH) or its analogue (HOE 766) administered for early ovulation timing increased pregnancy rates from 34.0% in untreated women to 51.1% in treated women by the third insemination cycle.
• The study suggests that early administration of ovulation-inducing or timing substances can prevent stress-induced failures.
• LH-RH or its analogue should be administered after two unsuccessful insemination cycles, considering the high spontaneous pregnancy rate in the initial cycles.

Impact:

• Early intervention with LH-RH analogues can enhance the success rates of artificial insemination therapy.
• This approach can help reduce treatment failures attributed to stress-induced ovulation problems.
• Optimizing the timing of ovulation induction can improve patient outcomes and reduce the duration of infertility treatment.