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Leukemic optic neuropathy

G C Brown, J A Shields, J J Augsburger

    International Ophthalmology
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Acute undifferentiated leukemia can cause unilateral blindness in children due to optic nerve infiltration. This rare manifestation has a poor prognosis, even with current treatments.

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    Area of Science:

    • Ophthalmology
    • Pediatric Oncology
    • Hematology

    Background:

    • Acute undifferentiated leukemia (AUL) is a rare hematologic malignancy in children.
    • Ophthalmic complications of leukemia can occur but optic nerve involvement is infrequent.

    Observation:

    • An eight-year-old child presented with unilateral blindness.
    • The blindness was secondary to leukemic optic nerve head infiltration.

    Findings:

    • Autopsy revealed massive leukemic cell infiltration and hemorrhagic necrosis in the optic nerve head and peripapillary retina.
    • This specific manifestation of leukemia is uncommon.

    Implications:

    • Leukemic optic nerve infiltration carries a poor prognosis for life.
    • Current therapeutic strategies may be insufficient for managing this rare complication.