Single- versus multiple-dose comparative trial of desipramine hydrochloride: a double-placebo method

In a double-blind comparative trial utilizing the double-placebo method, depressed neurotic patients whose effective titrated dose of desipramine hydrochloride was 75, 100, or 150 mg were maintained, with equal efficacy, on once-a-day or multiple daily dose regimens. The data confirm that the safety of the once-a-day maintenance regimen (as measured by vital signs, laboratory tests, ECGs, and clinical adverse reactions) is comparable to the safety of the multiple daily dose regimen.