Related Experiment Video
Updated: Aug 15, 2026

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
Hypertension in the elderly: the time has come to treat
Insights
Antihypertensive therapy is effective for elderly patients over 65 with high blood pressure, despite previous concerns. Treatment is recommended for systolic pressure over 160 mm Hg or diastolic over 95 mm Hg.
Area of Science:
- Gerontology
- Cardiology
- Neurology
Background:
- Hypertension is a significant risk factor for cerebrovascular and cardiovascular disease in individuals over 65.
- The efficacy and risks of antihypertensive therapy in the elderly have been debated, with potential overemphasis on risks.
Purpose of the Study:
- To evaluate the necessity and efficacy of antihypertensive therapy in elderly patients.
- To propose revised treatment guidelines for hypertension in older adults.
Main Methods:
- Review of existing evidence on antihypertensive therapy in patients over 65.
- Development of a revised stepped-care treatment approach.
Main Results:
- The risks of antihypertensive therapy in the elderly may be overemphasized.
- Evidence suggests treatment is beneficial when systolic blood pressure exceeds 160 mm Hg or diastolic pressure exceeds 95 mm Hg.
Conclusions:
- Elderly patients with specific blood pressure thresholds should receive antihypertensive treatment.
- A revised stepped-care approach, including vasodilating agents, is proposed for managing hypertension in older adults.
Abstract:
Both pure systolic, and systolic plus diastolic hypertension are risk factors for cerebrovascular and cardiovascular disease in patients over 65 years old, but the efficacy of antihypertensive therapy in preventing the complications of hypertension in the elderly has been questioned. The risks associated with such therapy seem to have been overemphasized. Although the evidence is incomplete, elderly patients should be treated when the systolic blood pressure exceeds 160 mm Hg or the diastolic pressure exceeds 95 mm Hg, or both. A revised stepped-care approach, with use of vasodilating agents as the Step-2 drugs, is proposed.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Drug Dosing: Geriatric Patients
Pharmacodynamics in Geriatric Patients: Effects of Age
Hypertension I: Introduction
Hypertension IV: Drug Therapy and Lifestyle Modifications
Hypertension V: Nursing Management