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Increased risk of group B streptococcal disease in twins

M S Edwards, C V Jackson, C J Baker

    JAMA
    |May 22, 1981
    PubMed

    Insights

    Infants from multiple births, like twins and triplets, face a higher risk of invasive group B streptococcal infections. This study examines these cases and proposes a treatment approach for unaffected siblings.

    Area of Science:

    • Neonatal Medicine
    • Infectious Diseases
    • Pediatrics

    Background:

    • Infants from multiple births represent a newly identified patient group with heightened susceptibility to invasive infections.
    • Group B Streptococcus (GBS) is a significant pathogen in neonates, causing early- and late-onset disease.

    Purpose of the Study:

    • To define the clinical and bacteriological characteristics of invasive GBS infections in infants from multiple births.
    • To explore reasons for increased susceptibility in these infants and their siblings.
    • To propose an empirical treatment strategy for the uninfected sibling of a neonate with invasive GBS infection.

    Main Methods:

    • Retrospective review of clinical data and microbiological findings.
    • Analysis of 11 twin sets and 1 triplet set with invasive GBS infection.
    • Clinical observation and case-based analysis.

    Main Results:

    • Eleven sets of twins and one set of triplets were identified with invasive GBS infections in one or more infants.
    • The study details the clinical presentations and bacteriological profiles of these infections.
    • Factors contributing to the increased susceptibility in multiple births are discussed.

    Conclusions:

    • Infants from multiple births are at increased risk for invasive GBS infections.
    • Understanding the susceptibility factors is crucial for prevention and management.
    • An empirical treatment approach for the uninfected sibling is suggested to mitigate risk.

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