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[Conjugated plasmids of antibiotic resistance in conditionally pathogenic enterobacteria in infants with
Insights
Opportunistic enterobacteria in children showed antibiotic resistance, particularly in salmonellosis cases. Conjugative resistance determinants were more frequent in these patients, mirroring Salmonella typhimurium resistance patterns.
Area of Science:
- Microbiology
- Pediatric infectious diseases
- Antimicrobial resistance
Background:
- Opportunistic enterobacteria are significant pathogens in pediatric infections.
- Antibiotic resistance in these bacteria poses a growing public health concern.
- Understanding resistance patterns in children, especially those with salmonellosis, is crucial.
Purpose of the Study:
- To investigate the antibiotic sensitivity of opportunistic enterobacteria in young children.
- To analyze the structure and frequency of conjugative drug resistance in these bacteria.
- To compare resistance patterns between healthy children and those with salmonellosis.
Main Methods:
- Isolation and identification of 1074 opportunistic enterobacteria strains from 117 children (aged 2 years).
- Testing sensitivity to 10 different antibiotics.
- Analysis of conjugative drug resistance determinants and their correlation with multidrug resistance.
Main Results:
- Opportunistic enterobacteria exhibited varying sensitivity to 10 antibiotics.
- The study characterized the structure and frequency of conjugative drug resistance.
- A higher frequency of conjugative antibiotic resistance determinants was observed in bacteria from children with salmonellosis.
- Resistance patterns in salmonellosis patients resembled transmissive R-plasmid resistance of Salmonella typhimurium.
Conclusions:
- Antibiotic resistance is prevalent in opportunistic enterobacteria in young children.
- Salmonellosis is associated with increased frequency of conjugative antibiotic resistance.
- Conjugative resistance mechanisms in these enterobacteria may be influenced by Salmonella infections.
Abstract:
Sensitivity to 10 antibiotics of 1074 strains of opportunistic enterobacteria isolated from 117 children at the age of 2 years was studied (57 healthy children and 60 children with salmonellosis). The structure of the conjugative drug resistance of the opportunistic enterobacteria, the frequency of their isolation and the spectrum correlating with multiple resistance of the strains to 4-10 antibiotics were shown. The frequency of the conjugative determinants of the antibiotics resistance in the opportunistic bacteria isolated from the patients with salmonellosis was higher. The structure of the conjugative drug resistance of the opportunistic enterobacteria in the dynamics of the salmonellosis process was close to the transmissive R-plasmid resistance of S. typhimurium.