Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced cancer

R Hoover, J F Fraumeni

    Cancer
    |March 1, 1981
    PubMed
    Summary

    Certain medications, particularly estrogenic compounds like DES, menopausal estrogens, and oral contraceptives, are linked to human cancer. Clinicians play a vital role in preventing drug-induced cancers by monitoring risks and benefits.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tobacco and alcohol use and oral cancer in Puerto Rico.

    Cancer causes & control : CCC·1999
    Same author

    The rising incidence of gastric cardia cancer.

    Journal of the National Cancer Institute·1999
    Same author

    Hip and knee implantations among patients with osteoarthritis and risk of cancer: a record-linkage study from Denmark.

    International journal of cancer·1999
    Same author

    Rising incidence of renal cell cancer in the United States.

    JAMA·1999
    Same author

    Lipid-lowering medication and risk of cancer.

    Journal of clinical epidemiology·1999
    Same author

    Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas.

    British journal of cancer·1999

    Area of Science:

    • Oncology
    • Pharmacology
    • Epidemiology

    Background:

    • Medicinal agents have been associated with human cancer development.
    • Estrogenic compounds, including diethylstilbestrol (DES), menopausal estrogens, and oral contraceptives, are under scrutiny.
    • Several other drugs require further epidemiologic evaluation for potential cancer links.

    Purpose of the Study:

    • To review medicinal agents linked to human cancer.
    • To highlight recent evidence on estrogenic compounds and cancer.
    • To emphasize the role of clinicians in preventing drug-induced cancer.

    Main Methods:

    • Literature review of drug-cancer associations.
    • Analysis of recent evidence implicating specific drug classes.
    • Discussion of clinical and public health implications.

    Main Results:

    • Estrogenic compounds (DES, menopausal estrogens, oral contraceptives) are implicated in human carcinogenesis.
    • Other drugs are under suspicion and require further investigation.
    • Identifying drug-cancer links informs clinical practice and carcinogenesis research.

    Conclusions:

    • Clinicians are crucial in preventing iatrogenic (drug-induced) cancer.
    • Alertness to hazards, risk-benefit assessment, and patient communication are key clinician roles.
    • Understanding drug-cancer associations provides insights into carcinogenesis mechanisms.

    Related Experiment Videos