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Diffuse histiocytic lymphoma after histologic conversion: a poor prognostic variant

J O Armitage, F R Dick, M P Corder

    Cancer Treatment Reports
    |May 1, 1981
    PubMed
    Summary
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    Histologic conversion to diffuse histiocytic lymphoma (DHL) occurred in patients with prior non-Hodgkin

    Area of Science:

    • Hematology
    • Oncology

    Background:

    • Diffuse histiocytic lymphoma (DHL) can arise from other non-Hodgkin's lymphomas (NHL) or chronic lymphocytic leukemia (CLL).
    • Histologic transformation represents a significant clinical challenge in lymphoma management.

    Purpose of the Study:

    • To investigate the clinical characteristics, treatment outcomes, and prognosis of patients who develop DHL following histologic conversion from a prior lymphoid malignancy.

    Main Methods:

    • Retrospective analysis of 15 patients diagnosed with DHL after prior lymphoma or leukemia.
    • Review of clinical presentations, time to transformation, treatment regimens, and survival data.

    Main Results:

    • The median time to DHL transformation was 47 months.
    • Common presentations included new or recurrent lymphadenopathy and hypercalcemia.

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  • Conventional chemotherapy regimens showed limited efficacy, with no long-term disease-free survival achieved.
  • Median survival after transformation was 12 months, indicating a poor prognosis.

    • Conclusions:

    • Histologic conversion to DHL is associated with a poor prognosis and limited treatment response.
    • Patients with DHL after histologic conversion may fare worse than those with de novo DHL.
    • Further research into novel therapeutic strategies for transformed lymphomas is warranted.