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Related Experiment Videos

Do carbohydrates promote hypertension?

B Fagerberg

    International Journal of Obesity
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated if a glycoside-hydrolase inhibitor impacts blood pressure by affecting insulin levels. While the inhibitor reduced insulin response to carbohydrates, it did not significantly alter blood pressure in obese hypertensive men.

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    Area of Science:

    • Endocrinology
    • Cardiovascular Research
    • Metabolic Syndrome

    Background:

    • Previous research suggests a link between plasma insulin levels and blood pressure, independent of body weight.
    • Dietary carbohydrate intake is associated with hyperinsulinemia, affecting sodium reabsorption and sympathetic activity, potentially influencing blood pressure.

    Purpose of the Study:

    • To investigate the effect of a glycoside-hydrolase inhibitor (BAY g 5421) on blood pressure and insulin response in obese men with borderline hypertension.
    • To explore the role of carbohydrate metabolism and insulin in hypertension management.

    Main Methods:

    • A pilot, randomized, double-blind, placebo-controlled study was conducted over three 4-week periods.
    • Six obese, middle-aged men with borderline hypertension received BAY g 5421 or placebo.

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  • Blood pressure, fasting glucose, fasting plasma insulin, and response to a 100g oral sucrose test were measured.

    • Main Results:

    • BAY g 5421 significantly reduced plasma insulin levels following the sucrose tolerance test compared to placebo.
    • No significant changes in systolic or diastolic blood pressure were observed after treatment with BAY g 5421 compared to placebo.
    • Body weight remained unchanged throughout the study.

    Conclusions:

    • The glycoside-hydrolase inhibitor effectively lowered insulin response to carbohydrate intake but did not demonstrate a significant impact on blood pressure in this pilot study.
    • Further investigation is required to determine if carbohydrate intake directly promotes hypertension.