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Updated: Aug 11, 2026

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
Published on: March 1, 2018
High-performance liquid chromatographic analyses of the antihypertensive drug captopril
Abstract:
High-performance liquid chromatographic systems have been developed to separate and quantitate captopril. The presence of interfering excipients in various formulations necessitated the development of three assays, each with distinctly different columns and mobile phases. All work well for bulk material, providing short analysis time, high precision, and rapid sample preparation, demonstrating that there is not necessarily one, best, high-performance liquid chromatographic system. The advantages and shortcomings of the ion-exchange, amino and octadecylsilane systems are evaluated and one of them is selected as optimum for bulk and tablet analysis.
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