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Related Experiment Videos

A proteolytic procoagulant associated with malignant transformation

S G Gordon

    The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
    |March 1, 1981
    PubMed
    Summary

    Cancer procoagulant, a cysteine protease unique to malignant cells, directly activates Factor X, promoting abnormal fibrin formation in cancer. This study confirms its neoplastic origin and role in cancer coagulation.

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    Area of Science:

    • Biochemistry
    • Oncology
    • Hematology

    Background:

    • Abnormal fibrin deposition and lysis are observed in cancer.
    • The specific causes of aberrant fibrin formation in malignancy remain largely unknown.

    Purpose of the Study:

    • To review existing research on cancer procoagulant.
    • To present preliminary immunohistochemical findings on cancer procoagulant.
    • To investigate the uniqueness of cancer procoagulant to the malignant state.

    Main Methods:

    • Purification of cancer procoagulant from rabbit V2 carcinoma.
    • Characterization of its physical, chemical, and enzymatic properties.
    • Assay of procoagulant activity in normal and malignant tissues and fibroblasts.
    • Immunohistochemical staining using an antibody to cancer procoagulant.

    Main Results:

    • Cancer procoagulant is a 68,000-dalton cysteine protease that directly activates Factor X.
    • Its properties distinguish it from coagulation serine proteases, suggesting a neoplastic origin.
    • Malignant tissues and transformed cells exhibit procoagulant activity similar to cancer procoagulant, unlike normal tissues.
    • Immunohistochemistry supports the presence of cancer procoagulant antigen in malignant cells.

    Conclusions:

    • Cancer procoagulant is a unique protein produced by neoplastic cells.
    • It plays a role in initiating coagulation and abnormal fibrin formation in cancer.
    • These findings support the hypothesis that malignant cells are the source of cancer procoagulant.

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