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[Hirsutism (author's transl)]

F Kuttenn, P Mauvais-Jarvis

    Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
    |April 1, 1978
    PubMed
    Summary

    Hirsutism is often caused by increased androgen production or utilization. Measuring plasma testosterone levels helps identify the cause, with further tests needed only for elevated levels suggesting rare conditions.

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    Area of Science:

    • Endocrinology
    • Dermatology

    Context:

    • Hirsutism, characterized by excess androgen activity, presents diagnostic challenges.
    • Understanding androgen metabolism is crucial for identifying hirsutism causes.

    Purpose:

    • To elucidate the etiological factors of hirsutism.
    • To establish diagnostic criteria for hirsutism based on androgen levels.

    Summary:

    • Hirsutism stems from increased androgen production (adrenals) or utilization (skin).
    • Plasma testosterone and androstenedione indicate production; skin 5-alpha-reductase and urinary 3-alpha-androstanediol reflect utilization.
    • Normal testosterone with regular cycles suggests idiopathic hirsutism; elevated levels in ovarian dystrophy are common. Levels >1.50 ng/ml warrant investigation for rare causes like tumors or congenital adrenal hyperplasia.

    Impact:

    • Provides a clear diagnostic pathway for hirsutism.
    • Differentiates common causes from rare, serious conditions.
    • Aids clinicians in appropriate patient management and further testing.

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