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Related Experiment Videos

Legionnaires' disease in children

R L Muldoon, D L Jaecker, H K Kiefer

    Pediatrics
    |March 1, 1981
    PubMed
    Summary

    Legionella pneumophila infection is common in children under 10, with seroreactivity increasing by age 1. This suggests Legionella may cause mild respiratory illness in young populations.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Microbiology
    • Immunology

    Background:

    • Legionella pneumophila is a significant cause of pneumonia in adults.
    • Data on the prevalence and impact of Legionella pneumophila infection in pediatric populations are limited.

    Purpose of the Study:

    • To investigate the seroreactivity to Legionella pneumophila in children under 10 years of age.
    • To determine the age of onset and prevalence of Legionella pneumophila infection in this demographic.
    • To explore the association between Legionella pneumophila infection and respiratory illness in children.

    Main Methods:

    • Retrospective analysis of sera from 126 children under 10 years old.
    • Measurement of seroreactivity titers to Legionella pneumophila.
    • Analysis of paired sera for serological rises indicative of recent infection.

    Main Results:

    • Seroreactivity was detected as early as 1 year of age, with geometric mean titers increasing with age.
    • At least 25% of children had high titers (≥256), suggesting past infection.
    • Three cases of significant serological rises were observed in children under 5, including two with pneumonia and one with bronchiolitis.

    Conclusions:

    • Infection with Legionella pneumophila, or a related agent, is common in children before 9 years of age.
    • Legionella pneumophila infection may be an underrecognized cause of mild respiratory disease in infants and children.
    • Further research is warranted to confirm the role of Legionella in pediatric respiratory infections.

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