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Related Experiment Videos

Adverse reactions to parenteral lincomycin

D D Berry, B H Brouhard, Q T Box

    Pediatrics
    |March 1, 1981
    PubMed
    Summary

    Parenteral lincomycin is a safe and effective antibiotic for treating Gram-positive bacterial infections in children. This study found a high cure rate with minimal adverse effects in pediatric patients.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Clinical Pharmacology
    • Antibiotic Therapy

    Background:

    • Parenteral lincomycin use in pediatric populations is not extensively documented.
    • Lincomycin has been widely utilized at the institution for pediatric infections.

    Purpose of the Study:

    • To evaluate the safety and efficacy of parenteral lincomycin in children.
    • To assess treatment outcomes for various pediatric infections treated with lincomycin.

    Main Methods:

    • Retrospective chart review of 265 pediatric patients receiving parenteral lincomycin.
    • Analysis of diagnoses, dosages, duration of therapy, administration routes, and adverse events.

    Main Results:

    • High cure rates observed across all treated conditions, including cellulitis, septic arthritis, osteomyelitis, abscess, lymphadenitis, and pneumonia.
    • Common pathogens identified were Staphylococcus aureus and Streptococcus pyogenes.
    • Parenteral lincomycin demonstrated a favorable safety profile with no administration site reactions and low incidence of diarrhea.

    Conclusions:

    • Parenteral lincomycin is a safe and effective antibiotic option for pediatric Gram-positive cocci infections.
    • The drug is well-tolerated in children, with a low risk of significant adverse events.

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