The proteins of human pancreatic external secretion

Human pancreatic external secretion is a mixture of proteins in solution in a strongly alkaline medium. 10% of proteins are constituted with non-digestive enzymes and proteins and mostly represented by serum-type proteins. 90% of proteins are digestive enzymes and zymogens necessary for digestion of proteins, lipids and carbohydrates present in diets. One prekallikrein is also secreted in pancreatic juice. The optimal pH of enzyme activities and the instability of most enzymes at acidic pH suggest that pancreatic secretion might not have a deleterious effect on gastric mucosa after duodenogastric reflux.