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Perinatal aspects of immunomodulation

C M Stern

    Agents and Actions. Supplements
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Haemopoietic stem cells develop into lymphocytes in fetal tissues. Maternal and fetal immune cells interact, influencing offspring immune responses and tolerance induction.

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    Area of Science:

    • Immunology
    • Developmental Biology
    • Hematology

    Background:

    • Haemopoietic stem cells originate from the yolk sac endoderm and migrate to fetal organs.
    • B-lymphocyte and T-lymphocyte precursors differentiate in specific fetal tissues, acquiring immune functions.
    • Immune tolerance and responsiveness are established during fetal development.

    Purpose of the Study:

    • To describe the migration and differentiation of immune cells during fetal development.
    • To analyze maternal-fetal immune cell interactions and their impact on immune responses.
    • To discuss models of immune diversity generation and potential therapeutic applications.

    Main Methods:

    • Observation of stem cell migration and lymphocyte differentiation in fetal tissues.

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  • Functional studies of maternal and fetal lymphocytes.
  • Analysis of chimerism in mothers and infants following blood transfusions.

    • Main Results:

    • Stem cells migrate to liver, bone marrow, and thymus, with B-cells differentiating in liver and bone marrow, and T-cells in the thymus.
    • Suppressor lymphocyte activity is present in both fetuses and mothers during pregnancy.
    • Maternal antigens can modulate fetal immune responses, and chimerism is observed in pregnant women and infants.

    Conclusions:

    • Fetal immune system development involves complex cell migration and differentiation processes.
    • Maternal-fetal immune interactions significantly influence the offspring's immune status.
    • Understanding these processes may lead to strategies for managing immune unresponsiveness and generating immune diversity.