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[Paget's bone disease and virus (author's transl)]

A Rebel, M Basle

    Annales De Pathologie
    |January 1, 1981
    PubMed
    Summary

    The cause of Paget's disease remains unclear, but evidence suggests a viral origin. Morphological and immunocytological studies of osteoclast inclusions support a link to paramyxoviruses like measles.

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    Area of Science:

    • Bone Biology
    • Virology
    • Pathology

    Context:

    • Paget's disease of bone etiology is debated despite numerous theories.
    • Inclusion bodies in osteoclasts were observed via electron microscopy in 1974, suggesting a viral link.

    Purpose:

    • To investigate the potential viral etiology of Paget's disease.
    • To analyze morphological and immunocytological evidence supporting a viral cause.

    Summary:

    • Osteoclast inclusions in Paget's disease exhibit morphological similarities to paramyxovirus nucleocapsids.
    • Immunocytological tests show antigenic material in osteoclasts reacting with anti-measles antibodies, indicating a potential measles virus connection.

    Impact:

    • Provides strong biological arguments supporting a viral etiology for Paget's disease.
    • This research contributes to understanding the pathogenesis of a century-old disease.

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