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Postprandial thermogenesis in obesity

P S Shetty, R T Jung, W P James

    Clinical Science (London, England : 1979)
    |May 1, 1981
    PubMed
    Summary

    Women with a family history of obesity show a reduced thermogenic response to meals. This metabolic difference may contribute to obesity, but other factors likely also play a role.

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    Area of Science:

    • Metabolic studies
    • Obesity research
    • Human physiology

    Background:

    • Family history of obesity is a significant risk factor.
    • Understanding the thermogenic response is crucial for obesity research.
    • Previous studies suggest metabolic differences in individuals with obesity.

    Purpose of the Study:

    • To investigate the thermogenic response to a liquid meal in lean, obese, and formerly obese women.
    • To examine changes in plasma substrates and hormones.
    • To assess the impact of a family history of obesity on metabolic responses.

    Main Methods:

    • A liquid meal was administered to participants.
    • Thermogenic response was measured.
    • Plasma glucose, insulin, thyroidal hormones, and noradrenaline levels were analyzed.

    Main Results:

    • Subjects with a family history of obesity exhibited a thermogenic response that was half that of the lean group.
    • Lean subjects showed a greater immediate plasma glucose and insulin response.
    • Venous noradrenaline levels increased postprandially in obese groups only.

    Conclusions:

    • Reduced postprandial thermogenesis in familial obesity lowers energy requirements.
    • Despite reduced thermogenesis, familial obesity groups had higher metabolic rates, suggesting additional defects.
    • Metabolic factors alone may not fully explain familial obesity.

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