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Calcitonin, a diabetogenic hormone?
The Journal of Clinical Endocrinology and Metabolism
|August 1, 1981
Summary
Calcitonin impairs glucose tolerance in humans by reducing insulin secretion and glucagon suppression. This hormone negatively impacts glucose metabolism in both normal and impaired glucose tolerance individuals.
Area of Science:
- Endocrinology
- Metabolism
Background:
- Calcitonin's role in glucose homeostasis is not fully understood.
- Investigating calcitonin's effects on glucose tolerance and related hormones is crucial.
Purpose of the Study:
- To investigate the effect of salmon calcitonin on oral glucose tolerance.
- To examine calcitonin's impact on insulin, C-peptide, glucagon, and growth hormone (GH) secretion.
Main Methods:
- Oral glucose tolerance tests (100g) were administered to 16 subjects (8 normal, 8 impaired glucose tolerance).
- Tests were conducted under basal conditions and during simultaneous salmon calcitonin administration.
- Plasma glucose, insulin, C-peptide, glucagon, and GH levels were measured.
Main Results:
- Calcitonin significantly worsened glucose tolerance in all subjects.
- Insulin and C-peptide responses to glucose were significantly reduced by calcitonin.
- Calcitonin partially prevented glucose-induced glucagon suppression and blunted the GH rebound.
Conclusions:
- Calcitonin impairs glucose tolerance by inhibiting insulin secretion and reducing glucagon suppression.
- These effects may be mediated by a decrease in cytosolic Ca2+ concentration in pancreatic alpha- and beta-cells.