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[Lymphomatous optic neuropathy (author's transl)]

T Takahashi, T Kondo, Y Isayama

    Klinische Monatsblatter Fur Augenheilkunde
    |May 1, 1981
    PubMed
    Summary

    Malignant lymphoma can affect the optic nerve, causing vision loss through orbital or intracranial lesions. Early recognition of symptoms like exophthalmos or cranial nerve palsy is crucial for timely treatment and potential vision recovery.

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    Area of Science:

    • Ophthalmology
    • Neurology
    • Oncology

    Background:

    • Malignant lymphoma can infiltrate the central nervous system and affect cranial nerves.
    • The optic nerve is susceptible to infiltration by lymphomatous processes, leading to visual impairment.

    Observation:

    • This report details seven cases of optic nerve involvement by malignant lymphoma.
    • Cases were categorized into orbital and intracranial lymphomatous optic neuropathy based on lesion location.
    • Orbital cases presented with rapid exophthalmos, phlegmone-like symptoms, and vision loss with central scotoma, often reversible.
    • Intracranial cases initially showed cranial nerve palsy, followed by rapid unilateral then bilateral vision loss.

    Findings:

    • Distinct clinical presentations differentiate orbital and intracranial lymphomatous optic neuropathy.
    • Histopathological findings in two autopsy cases provided insights into the causes of vision impairment.
    • Orbital lesions demonstrated reversible visual deficits, while intracranial lesions led to more severe and progressive vision loss.

    Implications:

    • Understanding these distinct patterns aids in the early diagnosis of lymphomatous optic neuropathy.
    • Prompt diagnosis and treatment are essential for preserving visual function in affected patients.
    • This classification aids in predicting prognosis and guiding therapeutic strategies for optic nerve lymphoma.

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