Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cefoxitin-associated renal failure

J Reddy, R R Bailey

    The New Zealand Medical Journal
    |May 27, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Cefoxitin sodium can cause acute kidney injury in elderly patients, particularly those with pre-existing renal impairment or when combined with gentamicin. Dosage adjustments or cautious use are recommended to prevent severe renal function deterioration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Over-prescription of short-acting β<sub>2</sub>-agonists for asthma in South Africa: Results from the SABINA III study.

    African journal of thoracic and critical care medicine·2023
    Same author

    Phenotypic correlates of the serotonin transporter gene.

    Acta neuropsychiatrica·2016
    Same author

    Stress Sampler I: psychosocial adjustment and psychiatric and physical comorbidity in diabetes mellitus.

    Acta neuropsychiatrica·2016
    Same author

    The Stress Sampler Study II: psychological functioning and coping within a diabetes sample.

    Acta neuropsychiatrica·2016
    Same author

    Labetalol in the treatment of patients with hypertension and renal function impairment.

    British journal of clinical pharmacology·2015
    Same author

    Labetalol in the treatment of a patient with phaechromocytoma: a case report.

    British journal of clinical pharmacology·2015
    Same journal

    Reed diffusers: a potential cause of poisoning in young children in New Zealand.

    The New Zealand medical journal·2026
    Same journal

    Stuffy nights: elevated bedroom carbon dioxide concentrations indicate inadequate ventilation in Wellington homes.

    The New Zealand medical journal·2026
    Same journal

    Cautionary tale of how sodium polystyrene sulfonate caused gut necrosis: a case report.

    The New Zealand medical journal·2026
    Same journal

    Emergency lateral canthotomy and cantholysis for acute globe subluxation.

    The New Zealand medical journal·2026
    Same journal

    Liberation of an incarcerated tibialis posterior tendon following a posterior malleolar ankle fracture: a case report.

    The New Zealand medical journal·2026
    Same journal

    Implementing a cultural safety training plan across medical colleges in Aotearoa New Zealand-looking back, and looking forward.

    The New Zealand medical journal·2026
    See all related articles

    Area of Science:

    • Nephrology
    • Pharmacology
    • Internal Medicine

    Background:

    • Cefoxitin is a cephalosporin antibiotic used for various infections.
    • Elderly patients and those with renal impairment are at higher risk for adverse drug events.
    • Concurrent use of antibiotics can increase the risk of nephrotoxicity.

    Observation:

    • Two elderly women experienced acute kidney injury following cefoxitin sodium treatment.
    • One patient with chronic renal failure due to reflux nephropathy had a fatal decline in renal function.
    • The second patient developed acute tubular necrosis while on cefoxitin and gentamicin for rheumatoid arthritis.

    Findings:

    • Evidence strongly suggests cefoxitin sodium was the primary cause of renal function deterioration in both cases.

    Related Experiment Videos

  • Acute tubular necrosis was diagnosed in one patient, indicating severe kidney damage.
  • The fatal outcome in one patient highlights the potential severity of cefoxitin-induced nephrotoxicity.

    • Implications:

    • Cefoxitin dosage requires careful reduction in patients with compromised renal function.
    • Combination therapy with cefoxitin and aminoglycoside antibiotics should be approached with extreme caution or avoided.
    • This study underscores the importance of monitoring renal function in elderly patients receiving cefoxitin, especially with concurrent nephrotoxic agents.