Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prophylactic cefazolin in gastric bypass surgery

W J Pories, A M van Rij, B T Burlingham

    Surgery
    |August 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk.

    The British journal of surgery·2016
    Same author

    Aortic aneurysm screening.

    The British journal of surgery·2015
    Same author

    Endothelial cell icam-1 staining in human carotid arteries.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Twenty-eight loci that influence serum urate levels: analysis of association with gout.

    Annals of the rheumatic diseases·2014
    Same author

    Evaluation of the accuracy of aorta scan BVI 9600 in screening for abdominal aortic aneurysm.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2014
    Same author

    Trace element profiles in cancer patients.

    Biological trace element research·2013

    Prophylactic cefazolin significantly reduced surgical site infections in gastric bypass patients. This antibiotic prophylaxis is effective, lowering wound infections from 21% to 4% and other infections from 17% to 0%.

    Area of Science:

    • Surgical Oncology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Obese patients undergoing surgery face elevated infection risks.
    • Gastric bypass surgery provides a model to evaluate prophylactic antibiotics.

    Purpose of the Study:

    • To assess the efficacy of cefazolin as a prophylactic antibiotic in gastric bypass surgery for morbid obesity.

    Main Methods:

    • A double-blind, prospective trial involving 53 patients randomized to cefazolin or placebo.
    • Serial cultures and antibiotic tissue levels were measured.
    • Postoperative infections were monitored by blinded clinicians.

    Main Results:

    • Cefazolin reduced wound infection incidence from 21% to 4% (P < 0.05).

    Related Experiment Videos

  • Incidence of urinary tract and pulmonary infections decreased from 17% to 0% (P < 0.05).
  • Adequate antibiotic tissue levels were confirmed.

    • Conclusions:

    • Perioperative cefazolin administration is highly effective in preventing infections after gastric bypass.
    • Results support reconsidering routine prophylactic antibiotic use in major surgeries.