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Red cell fragmentation in the dog: an editorial review
Veterinary Pathology
|July 1, 1981
Summary
This study details five types of red blood cell fragmentation in dogs, including microangiopathic, spherocytic, Heinz body, metabolic, and artifactual causes. These canine red blood cell fragmentation patterns are also observed in human medicine.
Area of Science:
- Veterinary Medicine
- Hematology
- Pathology
Background:
- Red blood cell (RBC) fragmentation in dogs presents diverse morphological and pathogenetic forms.
- Understanding these fragments is crucial for diagnosing various canine hematological disorders.
Purpose of the Study:
- To describe the morphology and pathogenesis of different types of RBC fragmentation in dogs.
- To compare canine RBC fragmentation patterns with those observed in human medicine.
Main Methods:
- Morphological examination of blood smears from dogs.
- Pathogenetic analysis of RBC fragmentation based on clinical and laboratory data.
Main Results:
- Identified five categories of RBC fragmentation: microangiopathic, spherocytic, Heinz body, metabolic, and artifactual.
- Microangiopathic fragmentation results from physical damage in abnormal capillaries.
- Spherocytic fragmentation is linked to immune-mediated hemolytic anemia and phagocyte activity.
- Heinz body fragmentation involves oxidized hemoglobin particles removed by the spleen.
- Metabolic fragmentation is associated with lipid metabolism abnormalities and cholesterol loading.
Conclusions:
- All described types of RBC fragmentation in dogs have parallels in human medicine.
- Recognizing these fragmentation types aids in veterinary diagnostics and comparative pathology.
