Related Experiment Video
Updated: Jul 12, 2026
08:31
Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro
Abstract:
The growth of Plasmodium falciparum in vitro was markedly inhibited by certain quassinoids (the bitter principles from plants of the family Simaroubaceae). The most active compound, simalikalactone D, gave complete inhibition at 0.005 microgram/ml. Glaucarubinone an soularubinone were equally effective at 0.006 microgram/ml, whereas chaparrinone and simarolide had little effect even at 0.01 microgram/ml. These relative activities are parallel to the antineoplastic activities of these materials.
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