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Updated: Oct 7, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
[Serum prolactin in obese subjects with glucose intolerance before and after treatment with phenformin]
Abstract:
10 obese subjects with latent glucose-intolerance we studied before and after a "short term" treatment with an oral antidiabetic drug, phenformina (100 mg/day for 14 days). The parameters we evaluated, were: basal IRI, C-peptide immunoreactive (IRCP), IRCP/IRI ratio, areas elicited by values of IRI after oral glucose tolerance test (OGTT), basal H-Prl, before and after the phenformin (F) treatment. Our data show that F decreases the basal IRI values but not IRCP values, so the IRCP/IRI ratio is significantly higher. No difference is found in the basal H-Prl values.
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