Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.5K

Ocular changes with oral and transepidermal diethylcarbamazine therapy of onchocerciasis

H R Taylor, B M Greene

    The British Journal of Ophthalmology
    |July 1, 1981
    PubMed

    Insights

    Topical diethylcarbamazine (DEC) lotion for ocular onchocerciasis showed no benefits over oral DEC. The lotion group experienced more ocular complications, suggesting oral treatment remains preferable for treating this infection.

    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Parasitology

    Background:

    • Onchocerciasis, caused by Onchocerca volvulus, is a significant cause of preventable blindness.
    • Ocular complications of onchocerciasis require effective and safe treatment strategies.

    Purpose of the Study:

    • To compare the safety and efficacy of oral diethylcarbamazine (DEC) versus topical DEC lotion for ocular onchocerciasis.
    • To evaluate potential ocular adverse events associated with each treatment method.

    Main Methods:

    • A double-masked, controlled clinical trial involving twenty men with moderate Onchocerca volvulus infection.
    • Assessment of visual acuity, color vision, visual fields, and ocular structures over a 6-month period.

    Main Results:

    • Both oral and topical DEC treatments resulted in fluffy corneal opacities and intraocular microfilariae.
    • The DEC lotion group showed a higher incidence of new chorioretinal changes and optic atrophy compared to the oral DEC group.
    • No significant changes in visual acuity or color vision were observed in either group.

    Conclusions:

    • Topical DEC lotion does not offer advantages over oral DEC for ocular onchocerciasis.
    • Topical DEC lotion may be associated with increased ocular complications compared to oral administration.

    More Related Videos

    A Standardized Approach to Extra-Oral and Intra-Oral Digital Photography06:49

    A Standardized Approach to Extra-Oral and Intra-Oral Digital Photography

    Published on: July 22, 2022

    10.3K
    Oral Biofilm Sampling for Microbiome Analysis in Healthy Children10:42

    Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

    Published on: December 31, 2017

    17.9K

    Related Concept Videos

    Oral Cavity01:11

    Oral Cavity

    The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
    Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
    3.2K
    Gene Therapy00:59

    Gene Therapy

    Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
    27.7K
    Group Therapy01:26

    Group Therapy

    Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
    450
    Oral Hypoglycemic Agents: Glinides01:06

    Oral Hypoglycemic Agents: Glinides

    Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
    680
    Psychosexual Stages of Personality: Oral01:16

    Psychosexual Stages of Personality: Oral

    The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
    Weaning, typically occurring...
    3.2K
    Assessing Body Temperature - Oral01:14

    Assessing Body Temperature - Oral

    Here are the steps to accurately measure oral temperature using an electronic thermometer:
    Step 1:
    Start by practicing proper hand hygiene to prevent the spread of microorganisms.
    Step 2:
    Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
    Step 3:
    Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
    Step 4:
    Instruct the patient to open their mouth and place...
    1.7K