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Genital herpes simplex

I S Tummon, D K Dudley, J H Walters

Canadian Medical Association Journal

|July 1, 1981

Summary

This summary is machine-generated.

Genital herpes, caused by the herpes simplex virus, can lead to unpredictable recurrences and poses risks for neonatal infection and cervical cancer. Currently, no effective treatment is available, necessitating monitoring during pregnancy.

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Area of Science:

Virology
Obstetrics
Gynecology

Background:

Genital herpes is a common sexually transmitted infection caused by the herpes simplex virus (HSV).
Following initial infection, HSV establishes latency in sacral ganglia, leading to unpredictable recurrences in about 80% of individuals.
Viral shedding can occur asymptomatically, posing transmission risks.

Purpose of the Study:

To highlight the clinical concerns associated with genital herpes, including neonatal transmission and potential links to cervical cancer.
To inform healthcare providers about the current lack of effective treatments for genital herpes.
To recommend a monitoring strategy for pregnant women at risk.

Main Methods:

Literature review on herpes simplex virus (HSV) latency, recurrence, and transmission.

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Analysis of the implications of maternal genital herpes on neonatal outcomes.

Review of potential associations between genital herpes and cervical cancer.

Evaluation of current management and monitoring guidelines for pregnant women.

Main Results:

Genital herpes is caused by HSV, which establishes lifelong latency.
Recurrences are common and can involve asymptomatic viral shedding.
Maternal genital herpes presents significant risks for neonatal herpes, a severe condition.
A potential association exists between genital herpes and cervical cancer.
No definitive cure or universally effective treatment for genital herpes is currently available.

Conclusions:

Genital herpes, caused by HSV, is a persistent viral infection with significant public health implications.
Pregnant women with a history of genital herpes or those with infected partners require careful management.
Weekly cervical cultures from 32 weeks gestation are recommended for high-risk pregnancies to monitor for viral shedding and prevent neonatal transmission.