Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ethanol abuse and heart disease

T J Regan, B Haider

    Circulation
    |September 1, 1981
    PubMed
    Summary

    Chronic ethanol abuse is toxic to the heart, causing cardiac dysfunction and arrhythmias. Cessation of alcohol intake may reverse alcoholic cardiomyopathy, but progression can continue in some individuals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    MRI analysis of simple and aneurysmal bone cysts in the proximal humerus: what actually matters in clinical routine.

    Skeletal radiology·2021
    Same author

    Impact of symptomatic skeletal events on health-care resource utilization and quality of life among patients with castration-resistant prostate cancer and bone metastases.

    Prostate cancer and prostatic diseases·2017
    Same author

    Choice of biodiversity index drives optimal fire management decisions.

    Ecological applications : a publication of the Ecological Society of America·2015
    Same author

    Neurofibrosarcoma in the nasal cavity.

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2012
    Same author

    Routine stress testing after percutaneous coronary interventions.

    Minerva cardioangiologica·2011
    Same author

    Clinical applicability of coronary atherosclerotic lesion characterization.

    Minerva cardioangiologica·2011

    Area of Science:

    • Cardiology
    • Toxicology
    • Gastroenterology

    Background:

    • Chronic ethanol abuse is known to cause cerebral and hepatic dysfunction.
    • The role of ethanol in heart disease is less clear, often attributed to malnutrition.
    • Malnutrition is not always present in patients with alcoholic cardiomyopathy.

    Purpose of the Study:

    • To investigate the toxic effects of chronic ethanol abuse on cardiac function.
    • To explore the role of ethanol as a direct cardiac toxic agent.
    • To understand the progression of alcoholic cardiomyopathy.

    Main Methods:

    • Animal studies demonstrating ethanol's cardiotoxic effects.
    • Comparison of animal model findings with human alcoholic cardiomyopathy.
    • Clinical data analysis of alcohol cessation and disease progression.

    Main Results:

    • Ethanol, in large amounts over prolonged periods, causes left ventricular dysfunction, metabolic, and morphologic changes in animals.
    • These changes parallel subclinical cardiac dysfunction in human alcoholics, including arrhythmias.
    • Nutritional deficiency is not consistently observed in alcoholic cardiomyopathy, suggesting ethanol's direct toxicity.

    Conclusions:

    • Ethanol is a direct cardiac toxic agent, independent of malnutrition.
    • Factors like cumulative exposure, intensified drinking, trace metals, and infection may contribute to disease progression.
    • Alcohol cessation can reverse or halt alcoholic cardiomyopathy in many, but not all, patients.

    Related Experiment Videos