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Updated: Aug 9, 2026
11:07
Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Summary
Corticosteroid binding globulin (CBG), also known as transcortin, is crucial for regulating cortisol levels. This review covers its properties, production, measurement, and variations, especially during pregnancy and oral contraceptive use.
Area of Science:
- Endocrinology
- Biochemistry
- Human Physiology
Background:
- Corticosteroid binding globulin (CBG), also known as transcortin, is the primary high-affinity plasma transport protein for cortisol.
- Understanding CBG is essential for interpreting cortisol levels and its physiological effects.
Purpose of the Study:
- To provide a comprehensive review of the current literature on corticosteroid binding globulin (transcortin).
- To detail its physicochemical properties, biosynthesis, measurement techniques, and variations.
- To emphasize the impact of pregnancy and oral contraceptives on CBG levels and function.
Main Methods:
- Literature review of scientific articles and studies on corticosteroid binding globulin.
- Synthesis of information regarding CBG's properties, production, and clinical relevance.
- Analysis of data related to physiological, pharmacological, and pathological variations.
Main Results:
- CBG exhibits specific physicochemical properties influencing steroid hormone transport.
- Its biosynthesis and measurement methods have been refined over time.
- Significant variations in CBG levels and function are observed during pregnancy and with oral contraceptive use, impacting cortisol bioavailability.
Conclusions:
- Corticosteroid binding globulin plays a vital role in regulating the bioavailability and physiological actions of glucocorticoids.
- Further research into CBG's implications is warranted for a complete understanding of endocrine function and disease states.
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